Mechano Growth Factor (MGF) — IGF-1 Ec Variant

Pharmaceutical Form: Peptide for reconstitution | Family: IGF-1 splice variant (IGF-1 Ec)

Presentation

Each 2ml multi-dose vial contains 2mg/vial, with Keifei® wording imprinted on the side. Vials feature a greenish-blue flip-off cap stamped with Keifei®. Supplied as:

• 3 × 2mg vials + 3 × 2ml ampoules of bacteriostatic water, seated in a plastic insert inside a white & blue box.
• One set of 10-digit authentication codes affixed to the plastic tray.

About MGF

Mechano Growth Factor (MGF) is a splice variant of IGF-1 (designated IGF-1 Ec in humans; IGF-1Eb in rodents). It is termed “mechano” because its RNA expression in muscle rises in response to mechanical overload and/or tissue damage.

Mechanism & Biology

• C-terminal (E-domain): A crucial region generated by alternative splicing (encoded by exon 5 and the first part of exon 6) that distinguishes MGF from other IGF-1 isoforms.
• Alternative splicing: A reading-frame shift produces a unique E-domain that can act functionally independent from the rest of the molecule.
• Differential actions: MGF is associated with satellite cell proliferation, whereas IGF-1 (other isoforms) more strongly induces myogenic differentiation.

Key Points

• Muscle-damage/overload–responsive IGF-1 splice variant.
• Unique E-domain underlies distinct bioactivity vs. canonical IGF-1.
• Often explored for roles in muscle repair and adaptive remodeling.

Authentication & Packaging

• Keifei® imprint on vial side; greenish-blue cap with Keifei® stamp.
• Plastic tray carries a 10-digit authentication code.
• Kit includes bacteriostatic water ampoules for reconstitution.

Important: Peptide products should be handled, reconstituted, and stored according to professional guidance and local regulations.